Sylvia Utami Tunjung Pratiwi, Ellen Louise Lagendijk, Sandra de Weert, Rinaldi Idroes, Triana Hertiani, Cees Van den Hondel
Biofilms are communities of microorganisms that can be found in almost every habitat. They can be attached to a surface and protected by an extracellular matrix of biomolecules that substantially protect microorganisms from environmental effects. The aim of this research is to explore the potency of essential oils from Cinnamomum burmannii Nees ex Bl. and Massoia aromatica Becc. against planktonic growth and biofilm formation of, two opportunistic pathogens, Pseudomonas aeruginosa PAO1 and Staphylococcus aureus Cowan I. Essential oil from C. burmannii and M. aromatica showed a 50% inhibition of P. aeruginosa and S. aureus planktonic growth (PMIC50) at concentration of 0.12 % v/v. Essential oil from C. burmannii and M. aromatica showed capability to inhibit 50% (MBIC50) of P. aeruginosa and S. aureus biofilm formation at concentration of 0.03 % v/v, whereas higher concentration (0.12 % v/v) was needed by C. burmannii and M. aromatica oil to disrupt 50% of P. aeruginosa and S. aureus established biofilm. The analysis by GC-MS showed cinnamic aldehyde (92.02 %) to be the major component of C. burmannii essential oil, whereas Massoialactone (92.05 %) was the main constituent of M. aromatica essential oil. The results obtained in this study have made the oil of C. burmannii and M. aromatica oil as an interesting source for antibiofilm agents in the development of new strategies to treat infections caused by P. aeruginosa and S. aureus biofilm. Industrial Relevance. Instead of freely swimming in solution (planktonic), in nature microbial tends to adhere to surfaces, and develop microbial biofilms. Microbial biofilms are exhibits resistance to both antimicrobial drugs and the host defence systems, which often results in persistent and difficult-to-treat infections. This makes the discovery of anti-infective agents which are active against planktonic and biofilm microbial represents an important goal. Plant is an interesting source for finding novel antibiofilm compounds. They are rich source of new molecules with pharmacological properties for the development of new drugs. The present research reports the potency of Cinnamomum burmannii. and Massoia aromatica oils against planktonic growth and biofilm of, two opportunistic pathogens, Pseudomonas aeruginosa PAO1 and Staphylococcus aureus Cowan I. The results scientifically establish the efficacy of C. burmannii and M. aromatica oils as interesting sources for antibiofilm agents in the development of new strategies to treat and prevent biofilm associated infections. © 2008-2015.
Department of Molecular Microbiology and Biotechnology, Institute Biology Leiden, Leiden University, Sylviusweg 72, Leiden, 2333 BE, Netherlands; Department of Pharmaceutical Biology, Faculty of Pharmacy, Gadjah Mada University, Sekip Utara, Yogyakarta, 55281, Indonesia; Koppert Biological Systems, Veilingweg 14, Berkel en Rodenrijs, 2650 AD, Netherlands; Department of Pharmacy, Faculty of Mathematics and Natural Science, Syiah Kuala University, Jalan Syech Abdurrauf No. 3, Darussalam-Banda Aceh, 23111, Indonesia
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