M. Munira, N. Zakiah, M. Nasir
In this study, we determined chemically active compounds extracted from Syzygium cumini stem using four different solvents, ethyl acetate, n-hexane, ethanol, and methanol. Gas Chromatography-Mass Spectrometry was used to investigate the chemical constituents in the targeted plant material and the in vitro antimalarial assay was evaluated through Giemsa staining microscopy utilizing the Plasmodium falciparum strain 3D7. The results indicate that the number of active compounds in the extract of ethyl acetate, n-hexane, ethanol, and methanol is 23, 7, 5, and 21 respectively, there are more compounds found in the ethyl acetate and methanol compared to ethanol and n-hexane. The antimalarial test confirmed that all four extracts were able to stop the growth of tested plasmodium but the ethyl acetate extract showed a remarkable ability to prevent the growth of plasmodium falciparum and completely inhibit it at the concentration of 100 µg/mL with the lowest IC50 of 11.08 µg/mL. The finding of this study could be useful for further development of natural product-based drugs for malaria disease treatment. © 2024, Rasayan Journal of Chemistry, c/o Dr. Pratima Sharma. All rights reserved.
Department of Pharmacy, Aceh Health Polytechnics, Aceh, Banda Aceh, Indonesia; Department of Biology, Faculty of Mathematics and Natural Science, Universitas Syiah Kuala, Aceh, Kopelma Darussalam, Banda Aceh, Indonesia
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