Darnifayanti Darnifayanti, Diva Rayyan Rizki, Shakira Amirah, Muhammad Fahd Abdurrahman, Muslim Akmal, S.N. Abdulmadjid, Sulaiman Yusuf, Muhammad Iqhrammullah
The objective of this systematic review and meta-analysis was elucidating the association of VDR SNPs (FokI, TaqI, BsmI, BgII, and ApaI) with neonatal sepsis. Literature search was performed to retrieve records published until August 2nd, 2023 (PROSPERO registration: CRD42023451355). Meta-analysis was carried out to determine the pooled estimates for Odds Ratio (OR). A total of four studies were included with 500 neonates (250 sepsis cases and 250 healthy controls). There was an association observed between TaqI SNP with neonatal sepsis for CT vs. CC+TT (OR=1.95) and TT vs CT+CC (OR=0.40). Moreover, the pooled estimates also suggested that CC vs. CT+TT (OR= 0.37) and C vs. T (OR=0.66) of FokI SNP were significantly associated with neonatal sepsis. SNP of BgII was found to be significantly associated with neonatal sepsis, but only reported in a single study. © 2024 The Authors
Graduate School of Mathematics and Applied Sciences, Universitas Syiah Kuala, Banda Aceh, 23111, Indonesia; Pediatric Department, Hospital of dr. Zainoel Abidin, Banda Aceh, 24415, Indonesia; Pediatric Department, Faculty of Medicine, Universitas Syiah Kuala, Banda Aceh, 23111, Indonesia; Medical Research Unit, School of Medicine, Universitas Syiah Kuala, Banda Aceh, 23111, Indonesia; Faculty of Medicine, Universitas Indonesia, Jakarta, 10430, Indonesia; Faculty of Veterinary Medicine, Universitas Syiah Kuala, Banda Aceh, 23111, Indonesia; Faculty of Mathematics and Natural Sciences, Universitas Syiah Kuala, Banda Aceh, 23243, Indonesia; Postgraduate Program of Public Health, Universitas Muhammadiyah Aceh, Banda Aceh, 23123, Indonesia
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