Dropout rate in clinical trials of smartphone apps for diabetes management: A meta-analysis

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Muhammad Iqhrammullah, Randa Yudhistira Refin, Fina Fitria Andika, Shakira Amirah, Muhammad Fahd Abdurrahman, Meulu Alina, Amanda Yufika, Asnawi Abdullah

2024 Diabetes Research and Clinical Practice Vol. 212 Review Cited by 12 SDG 3SDG 17 Quartile

Abstract

Applicability of smartphone-based digital health in diabetes management still face challenges due to low user retention or engagement. Thus, this systematic and meta-analysis aimed to estimate the dropout rate from the clinical trials. Search of literature was performed on 4 September 2023 through various databases (PubMed, Scilit, Scopus, Embase, and Web of Science). Those reporting clinical trials of smartphone apps for diabetic controls (either type 1 or type 2 diabetes mellitus) were screened and selected in accordance with PRISMA guideline. Of 5,429 identified records, as many as 36 studies were found eligible with a total of 3,327 patients in the intervention group. The overall dropout rate was 29.6 % (95 %CI: 25 %—34.3 %) with high heterogeneity (p-Het < 0.001; I2 = 84.84 %). Sample size, intervention duration, patients’ age and gender, and cultural adaptation on the app appeared to be non-significant moderators (p > 0.05). In sub-group levels, notably high dropout rates were observed in studies performing cultural adaptation (34.6 %) and conducted in high-income countries (31.9 %). Given the high dropout rate, the engagement level toward diabetic management apps in real-world setting is expected to be low. High heterogeneity in this study, however, requires careful interpretation of the foregoing results. PROSPERO: CRD42023460365 (14 September 2023). © 2024 Elsevier B.V.

Affiliations

Postgraduate Program of Public Health, Universitas Muhammadiyah Aceh, Banda Aceh, Indonesia; Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Medical Research Unit, Faculty of Medicine, Universitas Syiah Kuala, Banda Aceh, Indonesia; Department of Family Medicine, Faculty of Medicine, Universitas Syiah Kuala, Banda Aceh, Indonesia; Physical Medicine and Rehabilitation Residency Program, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Faculty of Public Health, Universitas Muhammadiyah Aceh, Banda Aceh, Indonesia

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