Tahara Dilla Santi, Tongku Nizwan Siregar, Amalia Sutriana, Rita Andini, Aditya Candra
Transdermal patches have been used for drug delivery to accelerate the wound healing process with minimum negative effect. This study evaluated the wound healing potential of transdermal patches containing Carica papaya, Chromolaena odorata, and Averrhoa bilimbi leaves extract on hyperglycemic rat as a diabetic wound model. For this purpose, a total of 40 Wistar rats aged 2-3 months were randomly distributed into 10 groups. The first 5 groups (P1, P2, P3, P4 and P5) consisted of normal rats which received normal dressing, TP Dermafix, TP of C. papaya, TP of C. odorata, and TP of A. bilimbi, respectively. The second 5 groups (P6, P7, P8, P9 and P10) were hyperglycemic rats that received normal dressing, TP Dermafix, TP of C. papaya, TP of C. odorata, and TP of A. bilimbi, respectively. Skin incisions were made perpendicular to the spine in the thickest part of the skin with an incision length of 2 cm and a depth of 0.5 cm. Patches were applied to the incisions according to the test group and replaced every 2 days for a period of 13 days. Wound healing activity was determined by evaluating the Clinical Sign of Inflammation (CSI) score, wound closure, TGF-β1 concentration, and histology of skin tissue. Data were analyzed using oneway analysis of variance (ANOVA). The results showed that for each parameter observed, the rats intervened with transdermal patches loaded with extract leaves had higher healing potential and different from the control group (normal dressing without intervene) both in normal and hyperglycemic rats. This made us concluded that the TP loaded with C. papaya, C. odorata, and A. bilimbi extract leaves have potential as wound healing agents and could be considered as alternate to the synthetic transdermal patches. © 2023, Walailak University. All rights reserved.
Graduate School of Mathematics and Applied Science, Universitas Syiah Kuala, Aceh, 23111, Indonesia; Faculty of Public Health, Universitas Muhammadiyah Aceh, Aceh, 23123, Indonesia; Laboratory of Reproduction, Faculty of Veterinary Medicine, Universitas Syiah Kuala, Aceh, 23111, Indonesia; Laboratory of Pharmacology, Faculty of Veterinary Medicine, Universitas Syiah Kuala, Aceh, 23111, Indonesia; Department of Forestry, Faculty of Agriculture, Universitas Syiah Kuala, Aceh, 23111, Indonesia; Faculty of Medicine, University of Abulyatama, Aceh, 24415, Indonesia
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