Rima Irwinda, Muhammad Alamsyah Aziz, Muhammad Ilham Aldika Akbar, Anak Agung Gede Raka Budayasa, Nuswil Bernolian, Julian Dewantiningrum, Makmur Sitepu, Siti Maisuri Tadjuddin Chalid, Cut Meurah Yeni, John Wantania, Mukhamad Nooryanto, Rabbania Hiksas
Objectives: Severe acute respiratory syndrome-coronavirus 2/COVID-19 infection is still a global concern, with pregnant women are considered as vulnerable population. Until now, the characteristics of pregnant women in Indonesia who are infected with COVID-19, as well as pregnancy and neonatal outcomes, are still unknown. This study aims to obtain national data, which are expected to be useful for the prevention and management of COVID-19 in pregnant women in Indonesia. Methods: There were 1,427 patients recruited in this retrospective multicenter study. This study involved 11 hospitals in 10 provinces in Indonesia and was carried out using secondary patient data from April 2020 to July 2021. COVID-19 severity was differentiated into asymptomatic-to-mild symptoms and moderate-to-severe symptoms. The collected data include maternal characteristics, laboratory examinations, imaging, pregnancy outcomes, and neonatal outcomes. Results: Leukocyte, platelets, basophil, neutrophils segment, lymphocytes, monocytes, neutrophil-to-lymphocyte ratio, platelet-to-lymphocyte ratio, alanine aminotransferase (ALT), aspartate aminotransferase (AST), C-reactive protein (CRP), urea, and creatinine were found to be significantly associated with severity differences (p < 0.05). Moderate–severe symptoms of COVID-19 also shown to have suggestive pneumonia findings on chest X-ray findings. Patients with asymptomatic-to-mild symptoms had significantly (p < 0.001) higher recovery rate, shorter hospital stay, less intensive care unit (ICU) admission, and had more vaginal delivery. Neonates from mother with mild symptoms also had significantly (p < 0.001) higher survival rate, higher birth weight, and higher APGAR score. Conclusion: Several laboratory and radiology components, as well as maternal and neonatal outcomes are related to the severity of COVID-19 in pregnant women in Indonesia. © The Author(s). 2023.
Department of Obstetrics and Gynecology, University of Indonesia, DKI Jakarta, Jakarta Pusat, Indonesia; Department of Obstetrics and Gynecology, Universitas Padjadjaran, West Java, Bandung, Indonesia; Department of Obstetrics & Gynecology, Faculty of Medicine, Universitas Airlangga, Surabaya, Surabaya, Indonesia; Department of Obstetrics and Gynecology, Warmadewa University/ Sanjiwani Hospital, Bali, Denpasar, Indonesia; Department of Obstetrics and Gynecology, RSMH, South Sumatera, Palembang, Indonesia; Department of Obstetrics and Gynecology, Dr. Kariadi Hospital/ Universitas Diponegoro, Semarang, Indonesia; Department of Obstetrics and Gynecology, H. Adam Malik Hospital/ Universitas Sumatera Utara, Medan, Indonesia; Department of Obstetrics & Gynaecology, Hasanuddin University, Sulawesi Selatan, Makassar, Indonesia; Department of Obstetrics and Gynecology, Dr. Zainoel Abidin Hospital/ Universitas Syiah Kuala, Aceh, Indonesia; Department of Obstetrics and Gynecology, RD Kandao Hospital/ Universitas Sam Ratulangi, Manado, Indonesia; Department of Obstetrics and Gynecology, Saiful Anwar Hospital/ Universitas Brawijaya, Malang, Indonesia
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