Ikhsan Ikhsan, Rinaldi Idroes, Azharuddin Azharuddin, Rosnani Nasution, Rika Yusnaini, Muhammad Iqhrammullah
An edible sea cucumber Holothuria atra has been hypothesized to have medicinal benefits against hyperuricemia owing to its bioactive compounds, including mono- and poly-unsaturated fatty acids. Herein, we aimed to investigate the fatty acids-rich extract produced from H. atra to treat hyperuricemic rats (Rattus novergicus). The extraction was carried out using n-hexane solvent and then administered to potassium oxonate-induced hyperuricemic rats, with allopurinol acting as a positive control. The extract (50, 100, 150 mg/kg body weight) and allopurinol (10 mg/kg) were administered QD through an oral route using a nasogastric tube. Serum uric acid, creatinine, aspartate aminotransferase (AST) and alanine aminotransferase (ALT), and blood urea nitrogen of the abdominal aortic blood were investigated. Our results suggested that the extract was rich in polyunsaturated (arachidonic acid) and monounsaturated fatty acids (oleic acid), in which its administration of 150 mg/kg could significantly reduce serum uric acid (p < 0.001), AST (p = 0.001), and ALT (p = 0.0302). The anti-hyperuricemic activity could be associated with the modulation of GLUT9 by the H. atra extract. In conclusion, the n-hexane extract from H. atra is a potential serum uric acid-lowering agent targeting GLUT9, where further investigations are crucially warranted. © 2023 by the authors.
Graduate School of Mathematics and Applied Sciences, Universitas Syiah Kuala, Banda Aceh, 23111, Indonesia; Department of Surgery, Tgk. Chik Di Tiro General Hospital, Sigli, 24116, Indonesia; Department of Chemistry, Faculty of Mathematics and Natural Sciences, Universitas Syiah Kuala, Banda Aceh, 23111, Indonesia; Department of Pharmacy, Faculty of Mathematics and Natural Sciences, Universitas Syiah Kuala, Banda Aceh, 23111, Indonesia; Department of Orthopedic and Traumatology, School of Medicine, Universitas Syiah Kuala, Banda Aceh, 23111, Indonesia; Department of Orthopedic and Traumatology, Dr. Zainoel Abidin Hospital, Banda Aceh, 24415, Indonesia; Department of Psychology and Nursing, Faculty of Medicine, Malikussaleh University, Lhokseumawe, 24351, Indonesia; Faculty of Public Health, Universitas Muhammadiyah Aceh, Banda Aceh, 23245, Indonesia
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