Fauzi Yusuf, Desi Maghfirah, Azzaki Abubakar, Teuku Irfan, Meutia Rizki Innayah
Background: Hepatocellular carcinoma (HCC) is the fifth most common cancer in the world, ranked second among the leading causes of death for all cancers. Treatment depends on the stage of the disease. Platelet activation is considered a part that plays a role in cancer development. Platelet distribution width (PDW) and mean platelet volume (MPV) are markers of platelet activation and are relatively affordable tests. Method: This research is an analytical study with a cross-sectional design and total sampling taken from medical records at Dr. Zainoel Abidin General Hospital in Banda Aceh. Staging of HCC was carried out using Barcelona Clinic Liver Cancer (BCLC) criteria. Spearman rank correlation test was used to assess the correlation coefficient between PDW and MPV values on the stage of HCC based on the BCLC criteria. The results were considered significant if the p-value <0.05. Result: This study involved 56 patients who were grouped into 4 grades of HCC based on BCLC criteria (16 patients with BCLC-A, 18 BCLC-B patients, 10 BCLC-C patients, and12 BCLC-D patients). Results of the Spearman rank correlation test showed the correlation coefficient of platelet distribution width (PDW) with the stage of HCC based on BCLC criteria was 0.79 (p>0.001), while the correlation coefficient of mean platelet volume (MPV) with the stage of HCC based on BCLC criteria was 0.74 (p<0.001). Conclusion: There is a strong correlation between PDW and MPV with the stage of HCC based on the BCLC criteria. PDW has a stronger correlation in predicting the stage of HCC based on the BCLC criteria than MPV. © 2023, Sanglah General Hospital. All rights reserved.
Gastroenterology-Hepatology Division, Internal Medicine Department, Universitas Syiah Kuala, Banda Aceh, Indonesia; Yarsi Hospital, Central Jakarta, Indonesia
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