Harapan Harapan, Raisha Fathima, Hendrix Indra Kusuma, Samsul Anwar, Widhy Yudistira Nalapraya, Adityo Wibowo, Ketut Dewi Kumara Wati, Ayunda Medina, Anna Hanifa Defrita, Yesi Astri, Arie Prasetyowati, Nurfarahin Nurfarahin, Afriyani Khusna, Setya Oktariana, Sarifuddin Anwar, Milza Oka Yussar, Siti Khotimah, Bahagia Willibrordus Maria Nainggolan, Putri Rizki Amalia Badri, Raden Argarini, Wira Winardi, Rosaria Indah, Malik Sallam, Yogambigai Rajamoorthy, Abram L. Wagner, Mudatsir Mudatsir
Obtaining a booster dose of coronavirus disease 2019 (COVID-19) vaccine is required to maintain the protective level of neutralizing antibodies and therefore herd immunity in the community, and the success of booster dose programs depends on public acceptance. The aim of this study was to determine the acceptance of a booster dose of COVID-19 vaccine and its drivers and barriers in Indonesia. A cross-sectional survey was conducted in the provinces of Indonesia between 1 and 15 August 2022. Individuals who completed the primary series of the COVID-19 vaccine were asked about their acceptance of a booster dose. Those who refused the booster dose were questioned about their reasons. A logistic regression was used to determine the determinants associated with rejection of a booster dose of COVID-19 vaccine. A total of 2935 respondents were included in the final analysis. With no information on the efficacy and safety of the COVID-19 vaccine, 95% of respondents agreed to receive a booster dose if it were provided for free by the government. This acceptance was reduced to only 50.3% if the vaccine had a 75% efficacy with a 20% chance of side effects. The adjusted logistic regression analysis indicated that there were eight factors associated with the rejection of the booster dose: age, marital status, religion, occupation, type of the first two vaccines received, knowledge regarding the importance of the booster dose, belief that natural immunity is sufficient to prevent COVID-19 and disbelief in the effectiveness of the booster dose. In conclusion, the hesitancy toward booster doses in Indonesia is influenced by some intrinsic factors such as lack of knowledge on the benefits of the booster dose, worries regarding the unexpected side effects and concerns about the halal status of the provided vaccines and extrinsic determinants such as the effectiveness and safety of the vaccine. These findings suggest the need for more campaigns and promotions regarding the booster dose benefits to increase its acceptance. © 2022 by the authors.
Medical Research Unit, School of Medicine, Universitas Syiah Kuala, Banda Aceh, 23111, Indonesia; Tropical Disease Centre, School of Medicine, Universitas Syiah Kuala, Banda Aceh, 23111, Indonesia; Department of Microbiology, School of Medicine, Universitas Syiah Kuala, Banda Aceh, 23111, Indonesia; Tsunami and Disaster Mitigation Research Center (TDMRC), Universitas Syiah Kuala, Banda Aceh, 23111, Indonesia; Department of Biology, Faculty of Mathematics and Natural Sciences, Universitas Syiah Kuala, Banda Aceh, 23111, Indonesia; Biology Education Department, Faculty of Tarbiyah and Teacher Training, Universitas Islam Negeri Ar-Raniry, Banda Aceh, 23111, Indonesia; Department of Statistics, Faculty of Mathematics and Natural Sciences, Universitas Syiah Kuala, Banda Aceh, 23111, Indonesia; Department of Pulmonology and Respiratory Medicine, Faculty of Medicine, Universitas Islam Bandung, Bandung, 40116, Indonesia; Department of Pulmonology and Respiratory Medicine, Faculty of Medicine, Universitas Lampung, Bandar Lampung, 35145, Indonesia; Department of Child Health, Faculty of Medicine, Universitas Udayana, Denpasar, 80234, Indonesia; Faculty of Medicine, Universitas Jambi, Jambi, 36373, Indonesia; Neurology Department, Faculty of Medicine, Universitas Muhammadiyah Palembang, Palembang, 30263, Indonesia; Mungkid Community Health Center, Magelang, 56512, Indonesia; Department of Pulmonology and Respiratory Medicine, Faculty of Medicine, Tadulako University, Palu, 94148, Indonesia; Faculty of Public Health, University Muhammadiyah Aceh, Banda Aceh, 23245, Indonesia; Biochemistry Laboratory, Medical Faculty of Mulawarman University, Samarinda, 75119, Indonesia; Undergraduate Program in Medicine, Faculty of Medicine, Universitas Sumatera Utara, Medan, 20155, Indonesia; Public Health Department, Faculty of Medicine, Universitas Muhammadiyah Palembang, Palembang, 30263, Indonesia; Department of Medical Physiology and Biochemistry, Universitas Airlangga, Surabaya, 60132, Indonesia; Department of Pulmonology and Respiratory Medicine, School of Medicine, Universitas Syiah Kuala, Banda Aceh, 23111, Indonesia; Medical Education Unit, School of Medicine, Universitas Syiah Kuala, Banda Aceh, 23111, Indonesia; Department of Pathology, Microbiology and Forensic Medicine, School of Medicine, The University of Jordan, Amman, 11942, Jordan; Department of Clinical Laboratories and Forensic Medicine, Jordan University Hospital, Amman, 11942, Jordan; Department of Translational Medicine, Faculty of Medicine, Lund University, Malmö, 22184, Sweden; Department of Economics, Faculty of Accountancy and Management, Universiti Tunku Abdul Rahman, Kuala Lumpur, 43200, Malaysia; Department of Epidemiology, School of Public Health, University of Michigan, Ann Arbor, 48109, MI, United States
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