Yusni Yusni, Hanifah Yusuf, Said Usman, Iflan Nauval, Hasanuddin Hasanuddin, Fahmi Ichwansyah, Nurul Mahmudati
Diabetes mellitus is a metabolic disorder characterized by chronic hyperglycemia and impaired glucose regulation. Brewed Arabica coffee (BAC, Coffea arabica L.) is widely consumed and contains bioactive compounds that have been associated with metabolic regulation, providing a rationale for investigating its potential effects on glucose homeostasis. This study investigated the antidiabetic potential of BAC in streptozotocin-induced diabetic rats. Male Wistar rats were divided into normal, diabetic, and BAC-treated diabetic groups (400 and 1200 mg/kg BW) for 28 days. Serum insulin, GLUT4, glucagon, and cortisol were assessed by ELISA. Compared with the diabetic control group, BAC significantly reduced glucose levels, with greater efficacy observed at the dose of 1200 mg/kg (p = 0.001). BAC treatment also improved GLUT4 and insulin concentrations and decreased glucagon and cortisol concentrations compared with the diabetic control group (p < 0.001). Correlation analysis revealed negative associations between glucose and both GLUT4 (r = −0.96) and insulin (r = −0.91) and positive correlations with glucagon (r = 0.89) and cortisol (r = 0.92). These findings demonstrate that BAC improves glucose regulation by modulating GLUT4, insulin, glucagon, and cortisol in streptozotocin-induced rats. Although both doses were effective, the higher dose produced superior metabolic outcomes. BAC may serve as a potential antidiabetic agent, warranting further investigation. Copyright © 2026 Yusni Yusni et al. Journal of Nutrition and Metabolism published by John Wiley & Sons Ltd.
Department of Physiology, Faculty of Medicine, Universitas Syiah Kuala, Banda Aceh, Aceh, 23111, Indonesia; Department of Pharmacology, Faculty of Medicine, Universitas Syiah Kuala, Banda Aceh, Aceh, 23111, Indonesia; Magister Program of Public Health, Medical Faculty, Universitas Syiah Kuala, Aceh, Banda Aceh, 23111, Indonesia; Family Medicine, Faculty of Medicine, Universitas Syiah Kuala, Banda Aceh, Aceh, 23111, Indonesia; Faculty of Agriculture, Universitas Syiah Kuala, Banda Aceh, Aceh, 23111, Indonesia; Master of Public Health, Universitas Muhammadiyah Aceh, Banda Aceh, Aceh, 23111, Indonesia; Biology Education Department, Faculty of Education, Universitas Muhammadiyah Malang, East Java, Malang, Indonesia
Research at a Glance
Register to unlock
Topics & SDG Alignment
Register to unlock
Collaboration
Register to unlock
Author Profile (Selected)
Register to unlock
References Overview
Register to unlock
Journal & Source
Register to unlock
Metadata & Integrity
Register to unlock