Budi Yanti, Rudi Agustika, T. Zulfikar
The coronavirus disease 2019 (COVID-19) pandemic has caused a global health crisis and is a source of increased morbidity and mortality in the world. COVID-19 caused by SARS-CoV-2 affects the proliferation of lymphocyte, but the clinical significance of lymphocyte remains unclear. Therefore, this study aims to analyze the relationship between lymphocyte with the clinical severity of COVID-19. The retrospective study design collected medical records of demographic data, chest X-rays, and laboratory tests at the time of hospital admission for confirmed patients. Furthermore, the severity of the disease was divided into moderate, severe, and very severe degrees. The severity of lung injury was assessed based on the Brixia Score, and the clinical outcome of patients had criteria of recovered and died. This study has collected 100 COVID-19 patients above 60 years (39%) with male gender (66%). The Majority of patients with low lymphocyte levels (51%), severe lung injury (45%), and one-third of the treated cases ended in death (33.0%), and most of them recovered (67%). Furthermore, low lymphocyte levels associated with severe and critically ill severity and died (p<0.05). Almost all lung damage was detected in severe and critically ill severity, and Brixia scores were detected high in patients with low lymphocyte levels (51.0%)(p>0.05). lymphocyte can be an indicator of clinical severity and mortality for COVID-19 patients. This study shows that lymphocyte count may help identify patients with severe disease. Therefore, observation of the lymphocyte count is necessary for the initial screening, diagnosis, and treatment of COVID-19 patients. © 2022. Malaysian Journal of Public Health Medicine.All Rights Reserved.
Department of Pulmonology and Medical Respirology, School of Medicine, Universitas Syiah Kuala, Banda Aceh, 24415, Indonesia
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