Darmadi Darmadi, Dharma Lindarto, Jelita Siregar, Tri Widyawati, Muhammad Rusda, Mustafa Mahmud Amin, Fauzi Yusuf, Putri Chairani Eyanoer, Masrul Lubis, Imelda Rey
Background: This study aims to determine the factors affecting HBV DNA suppression in chronic hepatitis B patients with tenofovir disoproxil fumarate (TDF). Methods: A case-control was carried out from October 2021 to August 2022 on 182 chronic hepatitis B patients who had TDF therapy regularly for 24 weeks at H. Adam Malik and USU Hospitals in Medan, Indonesia. The history of the samples was obtained, followed by physical examination, and blood collection. CTLA-4 polymorphism examination was carried out using real-time PCR, while the serum CTLA-4 levels were assessed with ELISA. Results: The CTLA-4 -1661G>A polymorphism, genotype GG+AG, increased 1.52 times risk of not achieving HBV DNA suppression to TDF compared to genotype AA (p=0.041). High CTLA-4 levels increased 2.28 times risk, high HBV DNA levels increased 2.09 times risk, low ALT levels increased 1.95 times risk of not achieving HBV DNA suppression (p= 0.009, 0.026, 0.036, respectively). There was no relationship between gender, age, ethnicity, obesity, baseline AST, HBeAg, genotype, liver fibrosis and HBV DNA suppression after 24 weeks of treatment (p>0.05). Conclusions: The levels of CTLA-4, HBV DNA, ALT, and CTLA-4 -1661G>A polymorphism have a potential relationship with the suppression of HBV DNA in chronic hepatitis B patients with TDF. Copyright: © 2023 Darmadi D et al.
Department of Internal Medicine, Faculty of Medicine, Universitas Sumatera UtaraNorth Sumatera, Medan, 20155, Indonesia; Philosophy Doctor in Medicine Program, Faculty of Medicine, Universitas Sumatera UtaraNorth Sumatera, Medan, 20155, Indonesia; Department of Clinical Pathology, Faculty of Medicine, Universitas Sumatera UtaraNorth Sumatera, Medan, 20155, Indonesia; Department of Pharmacology and Therapeutic, Faculty of Medicine, Universitas Sumatera UtaraNorth Sumatera, Medan, 20155, Indonesia; Master Program in Tropical Medicine, Faculty of Medicine, Universitas Sumatera UtaraNorth Sumatera, Medan, 20155, Indonesia; Department of Obstetrics and Gynecology, Faculty of Medicine, Universitas Sumatera UtaraNorth Sumatera, Medan, 20155, Indonesia; Department of Psychiatry, Faculty of Medicine, Universitas Sumatera UtaraNorth Sumatera, Medan, 20155, Indonesia; Department of Internal Medicine, Faculty of Medicine, Universitas Syiah Kuala, Banda Aceh, 23111, Aceh, Indonesia; Department of Public Health, Faculty of Medicine, Universitas Sumatera UtaraNorth Sumatera, Medan, 20155, Indonesia
Research at a Glance
Register to unlock
Topics & SDG Alignment
Register to unlock
Collaboration
Register to unlock
Author Profile (Selected)
Register to unlock
References Overview
Register to unlock
Journal & Source
Register to unlock
Metadata & Integrity
Register to unlock