Yusni Yusni, Hanifah Yusuf
BACKGROUND: The effect of green coffee (GC) on blood pressure (BP) is still debated, but GC is thought to improve liver and kidney function. AIM: This study aimed to analyze the effect of the GC intervention on BP, liver, and kidney functions in obese model rats. METHODS: The research was a pre-clinical trial of pretest-posttest with control group design. Animals were divided into four groups: obese rats (G1), obese rats and GC (G2), obese rats and physical exercise (PE) (G3), and a combination of interventions (PE+GC) (G4). Data analysis used an independent sample t-test and analysis of variance; (p < 0.05). RESULTS: There was a different effect of the GC, PE, and PE+GC intervention on BP (186.50 ± 3.45 vs. 91.33 ± 1.96 p = 0.001*; 189.17 ± 2.93 vs. 119.50 ± 3.73 p = 0.001*; 191.8 3 ± 2.64 vs. 98.83 ± 3.76 p = 0.001*) in obese rats. There was a significant difference in Serum Glutamic Oxaloacetic Transaminase (SGOT) (p=0.001*), Serum Glutamic Pyruvic Transaminase (SGPT) (p = 0.001*), Blood urea nitrogen (BUN) (p = 0.001*), and Creatinine (p = 0.001*) before and after the intervention in the three groups (G2, G3, and G4). SGOT, SGPT, and Creatinine levels decreased significantly after PE, GC, and PE+GC intervention. On the other hand, BUN levels decreased significantly after GC and its combination intervention. Meanwhile, in the control group and the intervention of PE, it increased significantly. CONCLUSIONS: GC is more effective in lowering BP without causing impaired liver and kidney function in obese rats. © 2022 Yusni Yusni, Hanifah Yusuf.
Department of Physiology, Faculty of Medicine, Universitas Syiah Kuala, Aceh, Indonesia; Department of Pharmacology, Faculty of Medicine, Universitas Syiah Kuala, Aceh, Indonesia
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