Cut Meurah Yeni, Prima Nanda Fauziah, Ani Melani Maskoen, Rovina Ruslami, Johannes Mose
Preeclampsia is a multisystem disorder characterized by hypertension and proteinuria. Elevated soluble fms-like tyrosine kinase 1 (sFlt-1) and reduced placental growth factor (PlGF) levels are documented in preeclampsia patients. Oxidative stress is known to play a role in the etiopathogenesis of preeclampsia. Hence, antioxidants as physiological protective agents can be used in the treating preeclampsia. In this study, we assessed the antioxidant properties of curcumin in HUVEC cell line cultured in serums collected from normal and preeclamptic pregnant women. The levels of sFlt-1 and PlGF were measured with ELISA. We found that sFlt-1 level and sFlt-1/PlGF ratio decreased significantly (p<0.05) while PIGF level increased significantly (p<0.05) after the curcumin administration with concentrations ranged from 0.977–250 µg/mL. The levels of sFlt-1, PlGF, and sFlt-1/PlGF ratio in preeclampsia-induced cell were equal to those in normal cell after the addition of 7.813 µg/mL curcumin after 24 h incubation. Similar results were obtained for samples with 48 h incubation, in exception with PlGF level in preeclampsia-induced cell that required 31.250 µg/mL curcumin to be equal to that in normal cell line. In conclusion, curcumin to be used in treating preeclampsia, by restoring the balance between proangiogenic factor (PlGF) and antiangiogenic factor (sFlt-1). However, further studies are warranted to elucidate this potency. © 2020 EManuscript Technologies. All rights reserved.
Department of Obstetrics and Gynecology, Faculty of Medicine, Universitas Syiah Kuala, Banda Aceh, Indonesia; Department of Medical Laboratory Technology, Faculty of Health, Universitas MH. Thamrin Jakarta, Indonesia; Department of Oral Biology, Faculty of Dentistry, Universitas Padjadjaran, Bandung, Indonesia; Department of Pharmacology and Therapy, Faculty of Medicine, Universitas Padjadjaran, Bandung, Indonesia; Department of Obstetrics and Gynecology, Faculty of Medicine, Universitas Padjadjaran, Bandung, Indonesia
Research at a Glance
Register to unlock
Topics & SDG Alignment
Register to unlock
Collaboration
Register to unlock
Author Profile (Selected)
Register to unlock
References Overview
Register to unlock
Journal & Source
Register to unlock
Metadata & Integrity
Register to unlock