Muhammad N. Salim, Moma Silvia, Dwinna Aliza, Dian Masyitha, Cut D. Iskandar, Rusli Rusli, Sugito Sugito, Muhammad Hasan, Mustafa Sabri, Abdul Harris
The objective of the present research was to find out the efficacy of Jatropha latex cream in the epithelialization phase of wound healing in mice skin. A total of 9 male mice aged 2-3 months old and the bodyweight of 25-40 g were divided into three treatment groups. Group A was given basic cream, group B was given Jatropha latex cream (10%), and group C was given sulfadiazine. The 2 cm incision wound was made in the paravertebral area. Wound therapy was carried out twice a day for 7 days. All quantitative data were measured using ANOVA then followed by the Duncan test. The number of angiogenesis on A, B, and C was 4.67±1.20; 12.78±2.52; and 11.33±2.33, while a number of fibroblasts were 179.56±12.69; 90.56±8.23; and 99.11±7.04, respectively. The average deposition of collagen was 1.46±0.12; 1.89±0.10; and 1.74±0.06, respectively. The statistical test showed that the number of angiogenesis, fibroblast, and deposition of collagen on group B was significantly different (P<0.05) compared to group A and showed no significant difference compared to group C (P>0.05). In conclusion, Jatropha latex cream (10%) able to accelerate the epithelialization phase of wound healing in mice skin. © 2020 The Authors, published by EDP Sciences.
Laboratory of Pathology, Faculty of Veterinary Medicine, Universitas Syiah Kuala, Banda Aceh, 23111, Indonesia; Laboratory of Histology, Faculty of Veterinary Medicine, Universitas Syiah Kuala, Banda Aceh, 23111, Indonesia; Laboratory of Clinical Pathology, Faculty of Veterinary Medicine, Universitas Syiah Kuala, Banda Aceh, 23111, Indonesia; Laboratory of Anatomy, Faculty of Veterinary Medicine, Universitas Syiah Kuala, Banda Aceh, 23111, Indonesia; Laboratory of Pharmacology, Faculty of Veterinary Medicine, Universitas Syiah Kuala, Banda Aceh, 23111, Indonesia
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