Teuku Heriansyah, Indah Nur Chomsy, Kumboyono Kumboyono, Pinandita Annisa Pratiwi, Titin Andri Wihastuti
Background: The pathomechanism of CVD is a complex and multifactorial process. The primary mechanism of CVD is atherosclerosis. Inflammation in atherogenesis raises the risk of hypoxia, which will activate hypoxia-inducible factor-1α (HIF1A). Also, together with lipoprotein-associated phospholipase A2 (Lp-PLA2), an inflammatory mediator for atherogenesis. Purpose: This study aims to measure the hypoxia-inducible factor-1α (HIF1A) expression and its correlation to Lp-PLA2 expression at low-risk, intermediate, and high-risk CVD populations. Patients and Methods: The study used a correlational analysis method with a total sampling technique in 160 individuals in the risk population. The atherosclerosis risk group was analyzed using the Framingham Risk Score and categorized into low, intermedi-ate, and high-risk groups. Venous blood samples taken from respondents were measured using the ELISA method with Lp-PLA2 and HIF-1α as parameters. Data were analyzed using normality test, homogeneity test, one-way ANOVA, post hoc–Tukey HSD, and Pearson correlation. Results: The concentration of HIF1A had a very strong correlation with Lp-PLA2 expres-sion, both in the low-risk group (r = 0.512), intermediate (r = 0.512), and high (r = 0.715) (P <0.05). However, the concentrations of Lp-PLA2 did not match the FRS. Conclusion: HIF1A expression increased with increasing risk, while Lp-PLA2 expression decreased with increasing risk of atherosclerosis based on the FRS category. There is a significant correlation between HIF1A expression and Lp-PLA2 expression based on FRS. © 2020 Heriansyah et al.
Department of Cardiology and Vascular Medicine, Syiah Kuala University, Banda Aceh, 23111, Indonesia; Faculty of Medicine, Brawijaya University, Malang, 65145, Indonesia; Nursing Department, Faculty of Medicine, University of Brawijaya, Malang, 65145, Indonesia; Medical Study Program, Faculty of Medicine, Brawijaya University, Malang, 65145, Indonesia; Department of Biomedicine, Faculty of Medicine, Brawijaya University, Malang, 65145, Indonesia
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