Khairan Khairan, Lalla Aïcha Ba, Torsten Burkholz, Michaela Leroch, Matthias Hahn, Tanya Schwab, Markus Klotz, Karl-Herbert Schaefer, Claus Jacob
Purpose of Review: This article provides a brief overview of electrochemical potential-biological activity relationships of natural and synthetic cyclic sulfur-containing molecules against Steinernema feltiae, Botrytis cinerea, and Neuro 2a cell line (from murine neuroblastoma). Recent Findings: This article finds natural cyclic sulfur-containing molecules and their synthetic analogues were more reducing than glutathione (GSH) and therefore apparently did not react with GSH. The nematicidal assay indicated that cyclic disulfide compound of 1 (3-vinyl-4H-1,2-dithiin, 1,2-VDT) was more active against Steinernema feltiae with the LD50 value 151.93 ± 1.3 μM, while dithiole thione group compounds showed moderate activity against this nematode. The article also finds compound 7 (3H-1,2-dithiole-3-thione or dithiolethione, DT) has a strong activity against all different strains of Botrytis cinerea in the range concentration of 0.1–0.5 mM. This article also finds that compounds 3 (1,2-dithiane, 1,2-DT), 4 (1,5-dithiacyclooctane, 1,5-DTCO), and 7 (3H-1,2-dithiole-3-thione or dithiolethione, DT) possess some moderate activity on Neuro 2a cell lines. Summary: Antinematode, antifungal, and anticancer activity of cyclic sulfur-containing molecules indicated that they could be promising candidates for “green pesticides” or phytoprotectans and for cancer prevention. © 2019, Springer Nature Switzerland AG.
Department of Pharmacy, Universitas Syiah Kuala, Darussalam, Banda Aceh, Indonesia; Herbal Medicinal Research Centre, Universitas Syiah Kuala, Darussalam, Banda Aceh, Indonesia; Laboratoire d’Ingénierie Moléculaire et Biochimie Pharmacologique, Institut Jean Barriol, Université Paul Verlaine-Metz, 1 Boulevard Arago, Metz, 57070, France; Department of Applied Materials Engineering, Institute of Air Handling and Refrigeration (ILK), Dresden, Germany; Department of Biology, University of Kaiserslautern, Kaiserslautern, Germany; Department of Microsystems Technique, University of Applied Sciences, FH-Kaiserslautern, Standort-Zweibruecken, Germany; School of Pharmacy, Universitaet des Saarlandes, Saarbruecken, Germany
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