V. Kurnianda, F. Syahliza, S. Karina, S. Agustina, M. Ulfah, C. Octavina, A. Mardiah, M.R. Ramadhan, S. Purnawan
Isolation of active metabolite from Indonesian's Marine Sponge Spongionellapulchella has been conducted on July 2018. Active compound isolated based on bioassay-guided separation with several steps of chromatography. The rate of viability shows that IC 50 = 0.2 μg / mL against PANC-1 cell. The active compound know as C 28 H 51 N 2 O 2 determined by LCMS-ESI with molecular weight [M+H] + 447.3951m/z. Based on the FTIR spectrum shows that the active metabolite has functional groups at 3435.56 cm 1 as N-H secondary amines, 2853.39 cm 1 as C-H methyl, 2769.64 cm 1 as C-H methylene and the fingerprint region of amine at 1637.27 cm 1 as C-N imine. The active compound which knows as araguspongine, an indole alkaloid shows potential activity against PANC-1 cell. © 2018 Published under licence by IOP Publishing Ltd.
Department of Marine Science, Faculty of Marine and Fisheries, Syiah Kuala University, Banda Aceh, 23111, Indonesia; Marine Chemistry Laboratory, Faculty of Marine and Fisheries, Syiah Kuala University, Banda Aceh, 23111, Indonesia; Department of Chemistry, Biology and Marine Science, Faculty of Science, University of the Ryukyus, Nishihara, Okinawa, 903-0213, Japan
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