K.F. Jamil, S. Supargiyono, D. Syafruddin, N. Pratama, S. Silvy
An estimated of 3.3 million Indonesian population were infected with malaria. However, extensive genetic polymorphism of the field isolates msp-1 of P. falciparum represents a major obstacle for the development of malaria treatment. The aim of this study was to investigate the genetic diversity of msp-1 genotype in field isolates of P. falciparum collected in Aceh Province. A total of 90 patients with malaria (+) were selected from eleven district hospitals in Aceh from 2013-2015. Data were collected by anamnesis, complete physical examination and laboratory tests for msp-1. All protocols to diagnose malaria followed the WHO 2010 guideline. All samples were stored in Eijkman Biology Molecular Institute, Jakarta. Among 90 samples, 57.7% were male, and 42.3% were female with the most cases found between 21-30 years old. From the allele typing analysis of P. falciparum from Aceh; K1, MAD20, and RO33 allele types were identified. MAD20 type was the highest allele found in this study (57.9%). It was found in single and mixed infection. A moderate level of the mixed allele was also observed. © Published under licence by IOP Publishing Ltd.
Division of Tropical and Infectious Diseases, Department of Internal Medicine, Medical Faculty of Syiah Kuala University, Dr. Zainoel Abidin Hospital, Banda Aceh, Indonesia; Center for Tropical Medicine Faculty of Medicine, Gadjah Mada University, Yogyakarta, Indonesia; Eijkman Institute for Molecular Biology, Jakarta, Indonesia
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