Ratu Safitri, Ida Indrawati, Mas Rizky A. A. Syamsunarno, Mohammad Ghozali, Basri A. Gani, Ramdan Panigoro
Objective: The objective of this study is to determine anti-Mycobacterium tuberculosis (MTB) strain H37 Rv and iron chelation activities of sappan wood extract (SWE). Methods: The evaluation of minimum inhibitory concentration (MIC) and minimum bactericidal concentration (MBC) by proportion methods. Whereas the iron chelate in Lowenstein–Jensen (LJ) medium as the indicator of Mycobacterium growth and SWE effect. Results: The SWE has bacteriocidal to MTB of 10−3 and 10−5 dilutions in of all concentrations (250, 500, 750, 1000, 2000, 4000, 8000, and 16000 part per millions [ppm]) also bacteriostatic in concentration 50 and 100 ppm. Conclusion: The SWE at 100 ppm could inhibit 87% of the MTB in 10−3 and 10−5 dilutions, respectively, also to reduce to growth the colony of MTB, and has chelating effects of iron expression of LJ medium and MTB. © 2018 The Authors.
Department of Biology, Faculty of Mathematics and Natural Sciences, Universitas Padjadjaran, Bandung, Indonesia; Department of Biology, Universitas Padjadjaran, Bandung, Indonesia; Central Laboratory, Universitas Padjadjaran, Bandung, Indonesia; Department of Biomedical Science, Faculty of Medicine, Universitas Padjadjaran, Bandung, Indonesia; Department of Oral Biology, Dentistry Faculty, Universitas Syiah Kuala, Banda Aceh, Indonesia
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