Muslim Suardi, Q.A. Wangi, Salman, Erizal Zaini, D. Akmal
Formulations of slow released verapamil hydrochloride microcapsules using poly (3-hidroxybutyrate) [P(3HB)] as coating materials have been studied. Microcapsules were prepared by solvent evaporation method using drug-polymer ratio of 1:1, 1:2, and 1:3. Microcapsules obtained were evaluated by infrared spectroscopy, Scanning Electon Microscope (SEM), particle size distribution, percentage of drug loading, dissolution test and drug release kinetic study. In-vitro dissolution profile testing was performed using paddle method in phosphate buffer medium at pH 7,4. Infrared spectra showed that there was no chemical interactions between verapamil hydrochloride and P(3HB) during microencapsulation process. SEM testing showed that microcapsules were spheric in shape. Particle size distribution of verapamil hydrochloride microcapsules were in range of 34-340μm, influenced by concentration of P(3HB). The percentage of drug loading for Formula 1, 2 and 3 were of 36.3±0.93; 24.5±0.66 and 20.8±1.62%, respectively. The percentage of dissolution efficiency in formula 1, 2, and 3 were of 26.9±0.03; 25.6±0.27, and 23.6±0.12%, respectively. The release kinetic model of verapamil hydrochloride from microcapsules followed Langenburcher model equation. There were significant differences of efficiency of dissolution among formula (sig < 0.05) Incerasing the concentration of P(3HB) could increase the inhibition released of verapamil hydrochloride from the microcapsules. In conclusion, P(3HB) could be used in the microencapsulation formulation of verapamil hydrochloride for sustained drug delivery.
Faculty of Pharmacy, University of Andalas, Padang, West Sumatra, Indonesia; Department of Pharmacy, Faculty of Science, Syiah Kuala University, Banda Aceh, Indonesia
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