Azhari Gani, Aznan Lelo, Muhammad Yamin, Effendy De Lux Putra, Harun Al Rasyid Damanik
Coffee, a main source of caffeine, has controversial effects on cardiovascular health. We evaluated the association of caffeine levels with the levels of Cytochrome P450 Subfamily 1A2 (CYP1A2) and interleukine-6 (IL-6) in Acehnese coffee drinker with coronary heart disease (CHD) compared to who do not consumed coffee (non-coffee drinkers). Fourty eight Acehnese male with CHD consisted of 24 coffee drinkers and 24 non-coffee drinkers participated in this case-control study which was conducted in Cardiology Division of Internal Medicine and Heart Catheterization Laboratorium of dr. Zainoel Abidin General Hospital, Banda Aceh. Afternoon blood samples were collected to determine the levels of caffeine, CYP1A2 and IL-6. Data obtained were analyzed for the differences and its correlations. Plasma levels of caffeine and IL-6 in coffee drinkers were significantly higher compared to that in non-coffee drinkers. Although CYP1A2 levels in coffee drinkers appeared to be higher compared to that non-coffee drinkers, but it was not statistically significant (p=0,06). There was a significant correlation between the levels of caffeine with the levels of IL-6 (r=0.36; p=0.01), but there was no significant correlation between the levels of caffeine with the levels of CYP1A2 (r=0.23; p=0.12). The present study demonstrated that the levels of caffeine and IL-6 differ based on coffee consumer habit, not for CYP1A2 levels. It is only a significant association between the levels of caffeine with the levels of IL-6. © 2016, Sphinx Knowledge House. All rights reserved.
Cardiology Division, Internal Medicine Department, Faculty of Medicine, University of Syiah Kuala, Jl. Tgk. Daud Beureueh No.108, Kota Banda Aceh, Aceh, Indonesia; Pharmacology and Therapeutic Department, Faculty of Medicine, University of Sumatera Utara, Jl. dr. Mansyur No. 5, Medan, 20155, Indonesia; Cardiology Division, Internal Medicine Department, Faculty of Medicine, University of Indonesia, Jl. Diponegoro No. 71, Jakarta, 10430, Indonesia; Faculty of Pharmacy, University of Sumatera Utara, Jl. Almamater No. 5, Medan, 20155, Indonesia; Nutrition Department, Faculty of Medicine, University of Sumatera Utara, Jl. Universitas No. 1, Medan, 20155, Indonesia
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